Aminopyridines and Similarly Acting Drugs: Effects on by P. Lechat, S. Thesleff and W. C. Bowman (Eds.) PDF

By P. Lechat, S. Thesleff and W. C. Bowman (Eds.)

ISBN-10: 0080280005

ISBN-13: 9780080280004

Offers a close evaluate of present study into the organic results of aminopyridines and equally performing ingredients. It specializes in their results on ion channels, and at the alterations of contractility that they produce. The facets coated variety from biophysical reports of uncomplicated mechanisms of motion to the particular and capability scientific makes use of in human sufferers

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Additional resources for Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses. Proceedings of a IUPHAR Satellite Symposium in Conjunction with the 8th International Congress of Pharmacology, Paris, France, July 27–29, 1981

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6^, 3 5 7 - 3 8 2 . S c h a u f , C. L . , C. A. C o l t o n , J. S. C o l t o n and F. A . D a v i s ( 1 9 7 6 ) . A m i n o p y r i d i n e s and s p a r t e i n e as i n h i b i t o r s of m e m b r a n e p o t a s s i u m c o n d u c t a n c e . E f f e c t s o n M y x i c o l a g i a n t a x o n s and the l o b s t e r n e u ­ romuscular junction. J. P h a r m a c o l . E x p . T h e r . , 1 9 7 , 4 1 4 - 4 2 5 . S c h w a r z , J. R. and W. V o g e l ( 1 9 7 1 ) . P o t a s s i u m i n a c t i v a t i o n in s i n g l e m y e l i n a t e d n e r v e f i b r e s of X e n o p u s l a e v i s .

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A p o s s i b l e e x p l a n a t i o n of this p u z z l i n g f a c t is to a s s u m e t h a t r e b i n d ing of 4-AP is p r e v e n t e d or m u c h impeded if the c h a n n e l g a t e s are closed a t the r e s t i n g p o t e n t i a l . H e n c e r e s t o r a t i o n of b l o c k should b e e n h a n c e d e v e n at w e a k d e p o l a r i z a t i o n s at w h i c h the p r o b a b i l i t y , N , of g a t e s to b e o p e n is m u c h l a r g e r than at r e s t . 0522 a t V = 20 m V .

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Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses. Proceedings of a IUPHAR Satellite Symposium in Conjunction with the 8th International Congress of Pharmacology, Paris, France, July 27–29, 1981 by P. Lechat, S. Thesleff and W. C. Bowman (Eds.)


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